History of Cialis

Statistics show that one in ten men may suffer from erectile dysfunction. For many years now, Cialis has been a go to drug to treat ED, in order to maintain a satisfying and healthy sex life.

While Cialis has become one of the most popular ED treatments on the market, Cialis has an interesting history. In fact, Cialis was discovered quite on accident.

The Beginnings

The story begins in 1994 with the discovery of another drug, called sildenafil, another type of phosphodiesterase drug, a PDE5 enzyme inhibitor, just as tadalafil is.

Often times the discovery of a drug is accidental; even the discovery of penicillin was accidental. In 1994 scientists from Pfizer began drug trials for a heart medication. This medication was called tadalafil. The beginning hope was that it could be a breakthrough medication for the treatment of many different pulmonary conditions.

During this trial of tadalafil many of the male participants reported unusual symptoms. Many of the men said that the drug made them experience unexplained erections.

When Pfizer announced that this compound worked in the same way as Viagra, the world began to take notice. This began to shed new light on the compound known as IC351. This made the scientists at ICOS take note, as they were also looking into this particular compound.

By 1998 the ICOS partnered with Eli Lilly to further develop this compound. In May 2002 this newly formed company was ready to tell the world about its new PDE5 enzyme inhibitor known as tadalafil.

The difference between this drug and sildenafil was its half-life, among other things. The half-life of Cialis was 17.5 hours, whereas Cialis had a four hour half-life. This would mean that Cialis could work up to thirty six hours after taking it.

In 2003, the American Urological Association received FDA approval of Cialis for erectile dysfunction. This led to direct competition with Pfizer’s drug Viagra. At the time when tadalafil came on the markets as FDA approved, it was the third drug available for erectile dysfunction.

 

What Does Cialis Treat?

Erectile dysfunction is not the only condition that Cialis is able to treat. It is also prescribed to treat benign prostatic hyperplasia (BPH). Cialis was approved in 2011 for the treatment of BPH.

In 2011 was Cialis was also approved for the treatment of BPH and ED combined. This came on the heels of the 2009 FDA approval of tadalafil for the treatment of pulmonary arterial hypertension (PAH).

Differences between Cialis and Other ED Medications

The three ED medications on the market are similar, but Cialis has some very distinct and popular differences. All of these medications work by inhibiting the PDE5 enzyme. The difference with tadalafil is that the half-life is longer. This has dubbed Cialis ‘the weekender pill.’

Furthermore, this half-life has led to the use of Cialis as either a daily treatment option, or on an as needed basis. This is the only one of the three erectile dysfunction medications that can be taken on an as needed basis.

It has also been noted that Cialis does not inhibit the PDE6 enzyme as much as the other two erectile dysfunction medications. This means that fewer side effects caused by the inhibiting of the PDE6 enzyme will not be seen in those taking Cialis.

Marketing of Cialis

The FDA relaxed rules in the United States on the marketing for prescription drugs. This allowed advertisers to directly target to its consumers. Cialis has taken advantage of its longer half-life in its advertising campaigns. Cialis markets spontaneity as the cornerstone of why the drug is more viable than its two competitors. In 2004 the three drug companies connected to erectile dysfunction drugs spent over three hundred and seventy million dollars to advertise the drugs.

Cialis has also been the sponsor of many sporting events including the PGA tour, the America’s Cup, and the Western Open Tournament.

Finding about Cialis Today

New studies have shown promise that Cialis may have potential cancer fighting properties. The specific cancers targeted are mouth and throat cancer. While Cialis can be used to treat a variety of other conditions, so far it has only approved it for use for erectile dysfunction, BPH, and PAH.

Interesting Facts about Cialis

When looking for the right erectile dysfunction medication, look to a couple of these quick facts to see if Cialis might be on target:

  • Cialis has very mild side effects and is typically very well tolerated. If mild side effects do occur, they will dissipate within a few hours.
  • Don’t mix nitrates with Cialis. This could cause a severe drop in blood pressure, always speak with a doctor when taking multiple medications.
  • Tadalafil can also be found under the brand name Adcirca. This medication dosage is the one prescribed for pulmonary arterial hypertension. Don’t take both Cialis and Adcirca as they are the same medication, but in different dosages.
  • Always be wary of fraudulent online pharmacies that tout generic Cialis. The generic of Cialis has not been approved by most government entities.
  • Cialis is more widely used than Viagra for its longer half-life and daily use options.
  • Cialis makes up the second largest market share, bringing in two billion dollars each year.
  • North America is the dominate market for these types of medication, as opposed to the rest of the world.
  • The price of Cialis in a brick and mortar pharmacy is almost twice as high as that of an online pharmacy. This is true of almost any medication.
  • Liquid Cialis does not exist; if an online pharmacy claims that it does, use a different pharmacy.

Impact of Erectile Dysfunction

Erectile dysfunction is the inability to achieve and maintain an erection for sexual activity. This can lead to a negative impact on self-esteem, cause performance anxiety, relationship issues, and further clinical depression. In a survey, sixty two percent of men had said that a decline in self-esteem was present, while twenty nine percent said ED had created a negative effect on relationships, and twenty one percent said that erectile dysfunction had led to relationships ending.

Thus, the role Cialis fills has proven to be a significant one in men’s physical, mental, and relational health.